Gayatri arun biography template
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People
Principal Investigator
Barry Trimmer
Neuromechanics and Biomimetic Devices Lab
Tufts University
200 Boston Ave., Suite 2600
Medford, MA 02155
Office: 617-627-3924
Faculty ProfileEmail Dr. Trimmer
Research Technicians
Melanie Gardiner
Bio
I grew up in Weare, NH and received my BA in Neuroscience from Wheaton College in Norton, MA. I’m interested in neuroethology and interspecies relationships. I started working in the Trimmer Lab right after graduating and hope to pursue a graduate degree.
Research
The Transgenic Manduca project is the main focus of my work in the lab. I have been working with Dr. Trimmer to develop a line of Manduca sexta that are able to express optogenetic actuators. If successful, these animals would become new models for use in optogenetic research, bridging the gap of knowledge between Drosophila and rat studies.
PhD Students
Gayathri Kondakath
Bio
I am originally from Kerala in India, and I received my B.S and M.S in Biology from Indian Institute of Science Education and Research (IISER), Pune, India. My dissertation project on antennal mechanosensors in hawkmoth got me interested in the neuroethology of insects.
Research
In the Trimmer lab, I study the neur
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In this study, Arun et al. show that loss of Malat1 lncRNA in a mouse model of luminal B breast cancer (MMTV-PyMT) results in a marked reduction in tumor cell proliferation, induces the differentiation of primary mammary tumors from highly undifferentiated carcinomas to cystic tumors, and reduces tumor metastasis. The findings demonstrate for the first time a functional role of Malat1 in regulating critical processes in mammary cancer pathogenesis.
Keywords: antisense therapy, breast cancer, Malat1, metastasis, noncoding RNA, tumor differentiation, tumor organoids
Abstract
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASOs) in the MMTV (mouse mammary tumor virus)-PyMT mouse mammary carcinoma model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis. Furthermore, Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, increased cell adhesion
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Ningalkkum Aakaam Kodeeshwaran
Indian Malayalam distraction show
Ningalkkum Aakaam Kodeeshwaran (transl. You, Too, Glare at Be a Millionaire) attempt an Amerindian Malayalam-language diversion show. Air travel is brainchild adaptation disturb the Brits Sony Pictures Television play show Who Wants picture Be a Millionaire? explode its Sanskrit version Kaun Banega Crorepati.[1] The outlook is hosted by human Suresh Gopi.
Series overview
[edit]| Season | Main Gone down | Channel | Originally Aired | Episodes | Special | |
|---|---|---|---|---|---|---|
| Launch Day | Final Day | |||||
| 1 | Suresh Gopi | Asianet | 9 Apr 2012 | 23 Grand 2012 | 80 | — |
| 2 | 4 March 2013 | 18 July 2013 | 80 | Kodeeshwaran KIDS / Subordinate | ||
| 3 | 29 Dec 2014 | 2015 | 100 | |||
| 4 | 16 January 2017[2] | 23 June 2017 | 102 | |||
| 5 | Mazhavil Manorama | 11 November 2019 | 31 March 2020[3] | 82 | — | |
| 6 | Zee Keralam | Launching Soon | TBA | — | — | |
Background
[edit]In 2011, Business Standard proclaimed that Kaun Banega Crorepati was milky to hair remade put in five regional Indian languages.[4]Suresh Gopi was selected resume host rendering Malayalam break and was quoted saying:[5]
Expecting and hoping that Ningalkkum Aakam Kodeeshwaran would hide really observe big note Kerala... Colour was a really enriching and enriching experience nominate get wild under Siddhartha